Setting description

several treatments more effective in distinctive signatures: (Hormone_therapies, TP53- & AR-); (Taxel_therapies, TEfus); (Carboplatin, DRD+)

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
—+ param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
–+- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
–++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
-+– param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+-+ param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-++- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+— param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
+–+ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
+-+- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
+-++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43
++– param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++-+ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+++- param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 6.3, median = 4.5 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 0.71, hr = 1.43 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++++ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 25, median = 18 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 2.85, hr = 0.33 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.129, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 7.6, median = 5.5 mean = 9.9, median = 7.1 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 0.87, hr = 1.16 af = 1.13, hr = 0.88 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.043, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 22.6, median = 16.3 mean = 9.9, median = 7.1 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 2.58, hr = 0.37 af = 1.13, hr = 0.88 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87
TP53+ param scale = 0.112, shape = 1.05 scale = 0.157, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 6.3, median = 4.5 mean = 9.9, median = 7.1 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 0.71, hr = 1.43 af = 1.13, hr = 0.88 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87
DRD+ param scale = 0.112, shape = 1.05 scale = 0.129, shape = 1.05 scale = 0.099, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 7.6, median = 5.5 mean = 9.9, median = 7.1 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 0.87, hr = 1.16 af = 1.13, hr = 0.88 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.129, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.098, shape = 1.05 scale = 0.098, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 7.6, median = 5.5 mean = 25, median = 18 mean = 10, median = 7.2 mean = 10, median = 7.2
effect af = 1, hr = 1 af = 0.87, hr = 1.16 af = 2.85, hr = 0.33 af = 1.14, hr = 0.87 af = 1.14, hr = 0.87

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 8 5 0 2
TP53- & AR- 323 2 1 2
TP53+ 1 25 7 5
DRD+ 0 0 164 172
TEfus+ 1 197 3 2
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.016 0.010 0.000 0.004
TP53- & AR- 0.646 0.004 0.002 0.004
TP53+ 0.002 0.050 0.014 0.010
DRD+ 0.000 0.000 0.328 0.344
TEfus+ 0.002 0.394 0.006 0.004
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 1 0 0 0
TP53- & AR- 3 86 43 51
TP53+ 275 0 0 0
DRD+ 33 5 0 0
TEfus+ 103 0 5 5
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.002 0.000 0.000 0.000
TP53- & AR- 0.006 0.172 0.086 0.102
TP53+ 0.550 0.000 0.000 0.000
DRD+ 0.066 0.010 0.000 0.000
TEfus+ 0.206 0.000 0.010 0.010
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 106 8 35 32
TP53+ 2 29 16 13
DRD+ 0 0 0 0
TEfus+ 0 33 1 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.212 0.016 0.070 0.064
TP53+ 0.004 0.058 0.032 0.026
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.066 0.002 0.000


Errors & power

The overall error was 0.064.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.010             0.030             0.012             0.014

The overall power was 0.894.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.646             0.394             0.328             0.344

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
all graduation 0 8 5 0 2
futility 0 1 0 0 0
max_n 0 0 0 0 0
n 462 (431, 493) 144 (85, 244) 188 (103, 254) 176 (116, 257) 181 (121, 254)
n_unique 423 (398, 451) 134 (78, 230) 174 (92, 237) 161 (105, 241) 165 (110, 238)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 4 (4, 7) 5 (4, 7) NA (NA, NA) 6 (5, 6)
post_p NA (NA, NA) 0.89 (0.19, 1) 0.99 (0.48, 1) 0.92 (0.25, 1) 0.86 (0.16, 1)
rate 0.094 (0.087, 0.102) 0.079 (0.062, 0.101) 0.071 (0.057, 0.091) 0.08 (0.064, 0.099) 0.081 (0.064, 0.103)
TP53- & AR- graduation 0 323 2 1 2
futility 0 3 86 43 51
max_n 0 106 8 35 32
n 198 (179, 217) 48 (26, 152) 41 (24, 100) 54 (27, 137) 55 (27, 140)
n_unique 183 (164, 202) 46 (25, 146) 36 (20, 95) 49 (24, 132) 48 (25, 131)
time_trial 36 (36, 36) 12 (7, 36) 36 (23, 36) 36 (36, 36) 36 (34, 36)
time_stop NA (NA, NA) 9 (6, 18) 20 (12, 32) 18 (12, 29) 19 (13, 32)
post_p NA (NA, NA) 1 (0.95, 1) 0.4 (0.01, 0.93) 0.45 (0, 0.96) 0.41 (0, 0.96)
rate 0.075 (0.067, 0.085) 0.043 (0.033, 0.052) 0.08 (0.053, 0.121) 0.076 (0.05, 0.117) 0.079 (0.051, 0.119)
TP53+ graduation 0 1 25 7 5
futility 0 275 0 0 0
max_n 0 2 29 16 13
n 200 (180, 222) 51 (27, 94) 108 (47, 144) 82 (50, 121) 84 (52, 123)
n_unique 183 (163, 203) 47 (25, 87) 100 (44, 133) 75 (45, 113) 77 (46, 115)
time_trial 36 (36, 36) 32 (13, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 20 (12, 32) 10 (7, 18) 10 (8, 14) 15 (10, 17)
post_p NA (NA, NA) 0.02 (0, 0.15) 1 (0.85, 1) 0.95 (0.46, 1) 0.92 (0.46, 1)
rate 0.113 (0.1, 0.126) 0.163 (0.137, 0.208) 0.067 (0.05, 0.09) 0.085 (0.063, 0.111) 0.088 (0.064, 0.112)
DRD+ graduation 0 0 0 164 172
futility 0 33 5 0 0
max_n 0 0 0 0 0
n 117 (100, 137) 24 (14, 39) 35 (19, 57) 79 (30, 107) 75 (31, 105)
n_unique 105 (89, 123) 22 (12, 36) 31 (17, 51) 73 (28, 99) 69 (28, 94)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (13, 36) 36 (14, 36)
time_stop NA (NA, NA) 28 (22, 35) 28 (22, 34) 18 (11, 34) 20 (11, 32)
post_p NA (NA, NA) 0.2 (0.02, 0.78) 0.81 (0.24, 0.99) 1 (1, 1) 1 (1, 1)
rate 0.092 (0.078, 0.106) 0.107 (0.072, 0.175) 0.068 (0.048, 0.1) 0.036 (0.028, 0.044) 0.036 (0.029, 0.044)
TEfus+ graduation 0 1 197 3 2
futility 0 103 0 5 5
max_n 0 0 33 1 0
n 170 (149, 189) 35 (23, 58) 112 (30, 144) 63 (40, 98) 62 (38, 98)
n_unique 153 (135, 172) 32 (20, 54) 102 (28, 133) 57 (35, 89) 56 (34, 89)
time_trial 36 (36, 36) 36 (24, 36) 36 (11, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 25 (16, 34) 14 (9, 30) 16 (12, 20) 18 (10, 33)
post_p NA (NA, NA) 0.07 (0, 0.46) 1 (0.99, 1) 0.7 (0.11, 0.98) 0.7 (0.13, 0.98)
rate 0.075 (0.065, 0.086) 0.103 (0.076, 0.143) 0.038 (0.031, 0.045) 0.067 (0.049, 0.094) 0.066 (0.05, 0.089)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- graduation 0 332 93 44 55
futility 0 0 0 0 0
max_n 0 106 8 35 32
n 132 (115, 148) 39 (21, 126) 14 (7, 78) 17 (7, 97) 16 (6, 100)
n_unique 122 (107, 139) 37 (20, 121) 12 (6, 75) 14 (5, 92) 14 (5, 96)
post_p NA (NA, NA) 1 (0.99, 1) 0.04 (0, 0.18) 0.03 (0, 0.14) 0.03 (0, 0.16)
rate 0.084 (0.072, 0.097) 0.043 (0.033, 0.053) 0.173 (0.131, 0.277) 0.168 (0.129, 0.294) 0.168 (0.134, 0.296)
—+ graduation 0 369 271 50 61
futility 0 0 0 0 0
max_n 0 103 39 36 32
n 23 (17, 31) 5 (2, 17) 13 (3, 25) 5 (2, 18) 5 (2, 16)
n_unique 21 (15, 28) 5 (2, 16) 12 (3, 23) 4 (2, 16) 4 (2, 14)
post_p NA (NA, NA) 0.69 (0.32, 0.92) 0.8 (0.42, 0.97) 0.13 (0.01, 0.31) 0.13 (0.03, 0.28)
rate 0.051 (0.035, 0.075) 0.045 (0.021, 0.101) 0.039 (0.022, 0.071) 0.179 (0.107, 0.445) 0.183 (0.107, 0.476)
–+- graduation 0 285 29 7 7
futility 0 0 0 0 0
max_n 0 2 29 16 13
n 66 (53, 79) 19 (8, 53) 24 (6, 58) 21 (5, 56) 26 (6, 56)
n_unique 61 (47, 73) 18 (7, 51) 21 (5, 55) 19 (5, 53) 24 (6, 52)
post_p NA (NA, NA) 0.33 (0.09, 0.76) 0.34 (0.08, 0.79) 0.29 (0.08, 0.75) 0.34 (0.1, 0.73)
rate 0.146 (0.122, 0.173) 0.17 (0.131, 0.277) 0.168 (0.126, 0.31) 0.173 (0.132, 0.335) 0.17 (0.131, 0.297)
–++ graduation 0 327 210 14 14
futility 0 0 0 0 0
max_n 0 2 60 17 13
n 49 (40, 60) 6 (3, 15) 40 (11, 55) 8 (3, 32) 8 (3, 30)
n_unique 45 (37, 56) 5 (2, 14) 37 (10, 52) 7 (3, 30) 7 (3, 28)
post_p NA (NA, NA) 0.16 (0.06, 0.36) 1 (0.94, 1) 0.15 (0.03, 0.36) 0.15 (0.03, 0.38)
rate 0.086 (0.067, 0.11) 0.182 (0.119, 0.393) 0.038 (0.027, 0.051) 0.172 (0.113, 0.391) 0.171 (0.112, 0.376)
-+– graduation 0 341 97 198 221
futility 0 0 0 0 0
max_n 0 104 8 32 31
n 21 (15, 29) 3 (0, 10) 4 (2, 10) 14 (4, 24) 13 (4, 23)
n_unique 19 (13, 27) 2 (0, 10) 3 (1, 9) 13 (4, 22) 12 (4, 21)
post_p NA (NA, NA) 0.68 (0.34, 0.92) 0.2 (0.07, 0.4) 0.91 (0.52, 0.99) 0.89 (0.49, 0.99)
rate 0.085 (0.059, 0.127) 0.047 (0.015, 0.134) 0.181 (0.096, 0.584) 0.035 (0.02, 0.069) 0.038 (0.02, 0.074)
-+-+ graduation 0 373 274 203 224
futility 0 0 0 0 0
max_n 0 101 39 33 31
n 21 (14, 29) 3 (0, 10) 6 (1, 16) 11 (4, 24) 12 (4, 23)
n_unique 19 (12, 26) 2 (0, 9) 5 (1, 14) 10 (3, 22) 10 (4, 22)
post_p NA (NA, NA) 0.51 (0.27, 0.81) 0.58 (0.27, 0.85) 0.66 (0.27, 0.91) 0.68 (0.3, 0.92)
rate 0.053 (0.035, 0.077) 0.049 (0.017, 0.132) 0.04 (0.018, 0.101) 0.036 (0.02, 0.072) 0.035 (0.02, 0.071)
-++- graduation 0 298 33 166 176
futility 0 0 0 0 0
max_n 0 2 29 12 13
n 12 (7, 18) 2 (1, 6) 3 (1, 7) 8 (2, 15) 8 (2, 15)
n_unique 11 (7, 16) 2 (0, 6) 2 (1, 6) 7 (2, 14) 7 (2, 14)
post_p NA (NA, NA) 0.35 (0.2, 0.59) 0.34 (0.17, 0.58) 0.93 (0.65, 1) 0.91 (0.56, 1)
rate 0.15 (0.099, 0.226) 0.184 (0.088, 0.696) 0.179 (0.083, 0.635) 0.037 (0.014, 0.085) 0.037 (0.014, 0.097)
-+++ graduation 0 334 213 173 180
futility 0 0 0 0 0
max_n 0 2 60 13 13
n 12 (8, 18) 2 (1, 5) 3 (0, 10) 7 (2, 15) 7 (2, 13)
n_unique 11 (7, 16) 2 (0, 4) 3 (0, 9) 7 (2, 13) 6 (2, 12)
post_p NA (NA, NA) 0.29 (0.13, 0.42) 0.67 (0.36, 0.93) 0.78 (0.44, 0.96) 0.77 (0.44, 0.96)
rate 0.085 (0.052, 0.14) 0.2 (0.093, 0.679) 0.041 (0, 0.152) 0.037 (0.017, 0.085) 0.038 (0.016, 0.086)
+— graduation 0 9 5 0 2
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 21 (15, 28) 8 (3, 20) 11 (3, 21) 7 (2, 18) 7 (2, 17)
n_unique 19 (13, 25) 7 (2, 18) 9 (3, 19) 7 (2, 17) 7 (2, 16)
post_p NA (NA, NA) 0.4 (0.16, 0.78) 0.42 (0.15, 0.82) 0.41 (0.17, 0.81) 0.43 (0.19, 0.82)
rate 0.148 (0.109, 0.206) 0.183 (0.112, 0.457) 0.171 (0.113, 0.404) 0.178 (0.108, 0.529) 0.174 (0.106, 0.511)
+–+ graduation 0 113 201 8 9
futility 0 0 0 0 0
max_n 0 0 33 1 0
n 18 (12, 25) 4 (2, 11) 13 (3, 23) 4 (2, 11) 4 (2, 12)
n_unique 16 (11, 23) 4 (1, 9) 12 (3, 21) 4 (1, 10) 4 (1, 11)
post_p NA (NA, NA) 0.26 (0.12, 0.51) 0.95 (0.66, 1) 0.25 (0.11, 0.49) 0.25 (0.11, 0.48)
rate 0.086 (0.056, 0.128) 0.183 (0.098, 0.47) 0.038 (0.02, 0.071) 0.202 (0.102, 0.605) 0.19 (0.1, 0.528)
+-+- graduation 0 285 29 7 7
futility 0 0 0 0 0
max_n 0 2 29 16 13
n 16 (11, 23) 5 (1, 14) 7 (3, 18) 6 (2, 16) 6 (2, 16)
n_unique 15 (10, 22) 4 (1, 13) 6 (2, 16) 6 (2, 15) 6 (2, 14)
post_p NA (NA, NA) 0.39 (0.2, 0.79) 0.42 (0.17, 0.8) 0.41 (0.19, 0.81) 0.37 (0.18, 0.77)
rate 0.146 (0.105, 0.21) 0.192 (0.11, 0.583) 0.176 (0.114, 0.421) 0.179 (0.106, 0.511) 0.195 (0.115, 0.464)
+-++ graduation 0 327 210 14 14
futility 0 0 0 0 0
max_n 0 2 60 17 13
n 18 (13, 25) 4 (1, 10) 12 (3, 22) 4 (2, 12) 5 (2, 13)
n_unique 16 (11, 22) 3 (1, 9) 11 (3, 20) 4 (1, 11) 4 (2, 12)
post_p NA (NA, NA) 0.28 (0.12, 0.51) 0.95 (0.68, 1) 0.25 (0.1, 0.47) 0.25 (0.1, 0.48)
rate 0.087 (0.056, 0.134) 0.183 (0.106, 0.516) 0.039 (0.023, 0.07) 0.189 (0.106, 0.472) 0.181 (0.105, 0.453)
++– graduation 0 42 10 164 174
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 12 (8, 17) 3 (1, 6) 3 (1, 7) 8 (2, 15) 8 (2, 15)
n_unique 11 (7, 16) 3 (1, 6) 3 (1, 6) 7 (2, 14) 7 (2, 14)
post_p NA (NA, NA) 0.34 (0.18, 0.56) 0.33 (0.18, 0.59) 0.94 (0.6, 1) 0.93 (0.61, 1)
rate 0.148 (0.1, 0.242) 0.193 (0.094, 0.576) 0.192 (0.094, 0.719) 0.037 (0.016, 0.085) 0.038 (0.015, 0.092)
++-+ graduation 0 132 205 171 178
futility 0 0 0 0 0
max_n 0 0 33 1 0
n 12 (8, 18) 3 (1, 6) 4 (1, 11) 7 (2, 15) 7 (2, 13)
n_unique 11 (7, 16) 2 (1, 5) 3 (1, 10) 7 (2, 14) 6 (2, 12)
post_p NA (NA, NA) 0.25 (0.12, 0.44) 0.7 (0.38, 0.93) 0.77 (0.44, 0.96) 0.77 (0.37, 0.96)
rate 0.086 (0.051, 0.144) 0.185 (0.096, 0.59) 0.04 (0.011, 0.109) 0.038 (0.017, 0.088) 0.037 (0.016, 0.117)
+++- graduation 0 298 33 166 176
futility 0 0 0 0 0
max_n 0 2 29 12 13
n 12 (7, 18) 2 (1, 6) 3 (1, 7) 8 (2, 16) 8 (2, 14)
n_unique 11 (6, 16) 2 (0, 5) 3 (1, 7) 7 (2, 14) 7 (2, 13)
post_p NA (NA, NA) 0.34 (0.2, 0.56) 0.34 (0.17, 0.59) 0.93 (0.59, 1) 0.92 (0.59, 1)
rate 0.149 (0.102, 0.233) 0.206 (0.097, 0.747) 0.186 (0.091, 0.588) 0.037 (0.015, 0.089) 0.037 (0.015, 0.087)
++++ graduation 0 334 213 173 180
futility 0 0 0 0 0
max_n 0 2 60 13 13
n 12 (8, 18) 2 (1, 5) 4 (0, 11) 7 (2, 15) 7 (2, 14)
n_unique 11 (7, 16) 2 (0, 5) 3 (0, 10) 6 (2, 13) 6 (2, 13)
post_p NA (NA, NA) 0.27 (0.13, 0.41) 0.69 (0.36, 0.92) 0.76 (0.41, 0.96) 0.77 (0.47, 0.96)
rate 0.089 (0.054, 0.144) 0.215 (0.101, 0.71) 0.042 (0.011, 0.145) 0.038 (0.018, 0.091) 0.038 (0.014, 0.085)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 8 5 2
time_stop 4 (4, 7) 5 (4, 7) 6 (5, 6)
n_trt 30 (25, 50) 27 (26, 41) 33 (27, 39)
n_control 52 (46, 72) 60 (45, 83) 65 (63, 67)
post_p 0.93 (0.87, 0.97) 0.89 (0.87, 0.96) 0.94 (0.91, 0.98)
order 1 (1, 1.3) 1 (1, 1) 1 (1, 1)
TP53- & AR- count 323 2 1 2
time_stop 9 (6, 19) 13 (13, 13) 20 (20, 20) 12 (10, 13)
n_trt 34 (26, 75) 31 (27, 35) 45 (45, 45) 26 (25, 26)
n_control 42 (28, 94) 54 (51, 57) 96 (96, 96) 55 (53, 57)
post_p 0.94 (0.87, 1) 0.95 (0.92, 0.98) 0.95 (0.95, 0.95) 0.97 (0.95, 0.98)
order 1 (1, 2) 2 (2, 2) 3 (3, 3) 2.5 (2.1, 2.9)
TP53+ count 1 25 7 5
time_stop 7 (7, 7) 10 (7, 18) 10 (8, 14) 15 (10, 17)
n_trt 26 (26, 26) 37 (29, 55) 27 (26, 40) 34 (30, 46)
n_control 33 (33, 33) 53 (31, 93) 51 (41, 73) 76 (49, 96)
post_p 0.88 (0.88, 0.88) 0.98 (0.92, 1) 0.98 (0.95, 0.99) 1 (0.96, 1)
order 1 (1, 1) 2 (1, 2) 1 (1, 2.4) 2 (1, 2)
DRD+ count 164 172
time_stop 18 (11, 34) 20 (11, 32)
n_trt 39 (26, 88) 42 (26, 84)
n_control 50 (28, 105) 56 (29, 115)
post_p 1 (0.98, 1) 1 (0.97, 1)
order 2 (1, 3) 2 (1, 3)
TEfus+ count 1 197 3 2
time_stop 16 (16, 16) 14 (9, 30) 12 (11, 13) 10 (10, 10)
n_trt 25 (25, 25) 40 (27, 104) 25 (25, 26) 28 (26, 30)
n_control 62 (62, 62) 55 (33, 138) 49 (41, 60) 49 (42, 56)
post_p 0.87 (0.87, 0.87) 0.99 (0.93, 1) 0.96 (0.94, 0.97) 0.98 (0.97, 0.98)
order 3 (3, 3) 2 (1, 3) 2 (1.2, 2) 2 (2, 2)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 1
time_stop 4 (4, 4)
n_trt 26 (26, 26)
n_control 52 (52, 52)
post_p 0.06 (0.06, 0.06)
order 1 (1, 1)
TP53- & AR- count 3 86 43 51
time_stop 9 (8, 9) 21 (12, 32) 17 (12, 30) 19 (13, 32)
n_trt 31 (28, 34) 30 (25, 58) 28 (25, 61) 32 (25, 65)
n_control 37 (31, 37) 106 (52, 174) 90 (57, 155) 96 (56, 180)
post_p 0.27 (0.26, 0.28) 0.11 (0.01, 0.26) 0.1 (0.01, 0.26) 0.09 (0.01, 0.24)
order 1 (1, 1) 1 (1, 2) 1 (1, 2.8) 1 (1, 3)
TP53+ count 275
time_stop 20 (12, 32)
n_trt 36 (26, 67)
n_control 101 (54, 169)
post_p 0.02 (0, 0.1)
order 1 (1, 2)
DRD+ count 33 5
time_stop 28 (22, 35) 28 (22, 34)
n_trt 26 (25, 31) 27 (25, 36)
n_control 81 (56, 113) 92 (64, 113)
post_p 0.05 (0.01, 0.18) 0.08 (0.03, 0.16)
order 2 (1, 3) 2 (1.4, 2.6)
TEfus+ count 103 5 5
time_stop 25 (16, 34) 19 (15, 21) 29 (14, 34)
n_trt 30 (25, 53) 27 (26, 48) 31 (25, 63)
n_control 108 (61, 156) 72 (60, 83) 137 (60, 154)
post_p 0.02 (0, 0.11) 0.08 (0.01, 0.26) 0.03 (0.01, 0.14)
order 2 (1, 3) 2 (1, 2.6) 3 (1.4, 3.6)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8
time 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7) 4 (4, 7)
n 16 (10, 22) 2 (1, 5) 8 (4, 12) 1 (0, 4) 0 (0, 1) 0 (0, 3) 0 (0, 0) 0 (0, 1) 1 (0, 2) 2 (0, 2) 0 (0, 2) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 0 (0, 1)
post_p 0.85 (0.75, 0.92) 0.58 (0.53, 0.66) 0.72 (0.63, 0.79) 0.53 (0.51, 0.57) 0.56 (0.52, 0.61) 0.54 (0.52, 0.55) 0.6 (0.6, 0.6) 0.55 (0.55, 0.55) 0.59 (0.53, 0.63) 0.6 (0.51, 0.68) 0.67 (0.63, 0.71) 0.53 (0.52, 0.54) NA (NA, NA) 0.5 (0.5, 0.5) 0.63 (0.54, 0.72) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.022 (0, 0.044) 0 (0, 0.59) 0.094 (0.025, 0.13) 0 (0, 0.055) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.084) 0 (0, 0.102) 0 (0, 0.061) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0.485) 0.175 (0.175, 0.175)
Taxel_therapies count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
time 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7) 5 (4, 7)
n 5 (4, 8) 5 (1, 8) 3 (3, 6) 6 (5, 12) 0 (0, 0) 0 (0, 1) 0 (0, 2) 0 (0, 2) 1 (1, 3) 3 (0, 3) 1 (1, 4) 1 (0, 3) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0)
post_p 0.59 (0.52, 0.63) 0.58 (0.55, 0.79) 0.59 (0.52, 0.7) 0.68 (0.63, 0.77) NA (NA, NA) 0.53 (0.51, 0.54) 0.55 (0.54, 0.56) 0.59 (0.53, 0.65) 0.66 (0.52, 0.75) 0.6 (0.58, 0.69) 0.56 (0.53, 0.61) 0.67 (0.66, 0.72) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.056 (0.045, 0.071) 0 (0, 0.016) 0.129 (0.093, 0.164) 0 (0, 0.044) NA (NA, NA) 0 (0, 0) 0.181 (0.036, 0.325) 0 (0, 0) 0 (0, 0.178) 0 (0, 0.053) 0 (0, 0.261) 0 (0, 0.036) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA)
Niraparib count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6) 6 (5, 6)
n 1 (0, 2) 2 (1, 4) 4 (1, 6) 2 (0, 3) 4 (2, 6) 6 (5, 6) 4 (4, 4) 2 (0, 3) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 1) 2 (2, 3) 2 (0, 3) 2 (0, 3) 4 (2, 5)
post_p 0.52 (0.52, 0.52) 0.52 (0.52, 0.52) 0.54 (0.54, 0.54) 0.52 (0.52, 0.52) 0.52 (0.52, 0.53) 0.55 (0.55, 0.56) 0.64 (0.59, 0.69) 0.54 (0.54, 0.54) NA (NA, NA) 0.6 (0.6, 0.6) NA (NA, NA) 0.57 (0.57, 0.57) 0.62 (0.6, 0.63) 0.64 (0.64, 0.64) 0.59 (0.59, 0.59) 0.7 (0.56, 0.85)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0.054 (0.054, 0.054) 0 (0, 0) 0.031 (0.006, 0.055) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0.085 (0.017, 0.154) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53- & AR- Hormone_therapies count 323 323 323 323
time 9 (6, 19) 9 (6, 19) 9 (6, 19) 9 (6, 19)
n 28 (21, 63) 4 (2, 9) 1 (0, 4) 1 (0, 5)
post_p 0.95 (0.84, 1) 0.65 (0.52, 0.81) 0.57 (0.51, 0.75) 0.56 (0.51, 0.71)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.036 (0.014, 0.056) 0 (0, 0.066) 0 (0, 0.06) 0 (0, 0.036)
Taxel_therapies count 2 2 2 2
time 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13)
n 17 (15, 19) 8 (6, 9) 2 (1, 2) 5 (3, 7)
post_p 0.74 (0.71, 0.76) 0.93 (0.9, 0.96) 0.57 (0.55, 0.59) 0.71 (0.62, 0.8)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.084 (0.083, 0.086) 0.022 (0.021, 0.022) 0 (0, 0) 0 (0, 0)
Carboplatin count 1 1 1 1
time 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20)
n 28 (28, 28) 2 (2, 2) 4 (4, 4) 11 (11, 11)
post_p 0.76 (0.76, 0.76) 0.6 (0.6, 0.6) 0.74 (0.74, 0.74) 0.79 (0.79, 0.79)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.076 (0.076, 0.076) 0 (0, 0) 0.039 (0.039, 0.039) 0.014 (0.014, 0.014)
Niraparib count 2 2 2 2
time 12 (10, 13) 12 (10, 13) 12 (10, 13) 12 (10, 13)
n 12 (12, 12) 0 (0, 0) 10 (8, 12) 4 (2, 6)
post_p 0.74 (0.72, 0.75) NA (NA, NA) 0.85 (0.79, 0.9) 0.63 (0.54, 0.73)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.039 (0.035, 0.043) NA (NA, NA) 0.011 (0.002, 0.02) 0 (0, 0)
TP53+ Hormone_therapies count 1 1 1 1 1 1 1 1
time 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7)
n 14 (14, 14) 5 (5, 5) 1 (1, 1) 1 (1, 1) 4 (4, 4) 1 (1, 1) 0 (0, 0) 0 (0, 0)
post_p 0.79 (0.79, 0.79) 0.66 (0.66, 0.66) 0.56 (0.56, 0.56) 0.53 (0.53, 0.53) 0.65 (0.65, 0.65) 0.66 (0.66, 0.66) NA (NA, NA) NA (NA, NA)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.077 (0.077, 0.077) 0.082 (0.082, 0.082) 0 (0, 0) 0 (0, 0) 0.053 (0.053, 0.053) 0 (0, 0) NA (NA, NA) NA (NA, NA)
Taxel_therapies count 25 25 25 25 25 25 25 25
time 10 (7, 18) 10 (7, 18) 10 (7, 18) 10 (7, 18) 10 (7, 18) 10 (7, 18) 10 (7, 18) 10 (7, 18)
n 12 (5, 21) 14 (6, 22) 1 (0, 3) 1 (0, 4) 4 (2, 6) 4 (1, 10) 0 (0, 3) 1 (0, 3)
post_p 0.76 (0.7, 0.88) 0.84 (0.75, 0.97) 0.56 (0.52, 0.64) 0.61 (0.52, 0.67) 0.59 (0.52, 0.84) 0.7 (0.58, 0.95) 0.57 (0.52, 0.68) 0.58 (0.54, 0.71)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.1 (0.041, 0.141) 0.033 (0.007, 0.059) 0 (0, 0.149) 0 (0, 0.044) 0.102 (0.036, 0.196) 0 (0, 0.056) 0.062 (0, 0.131) 0 (0, 0.081)
Carboplatin count 7 7 7 7 7 7 7 7
time 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14)
n 10 (5, 14) 4 (1, 9) 3 (2, 4) 2 (1, 3) 2 (0, 3) 3 (1, 5) 5 (3, 6) 2 (0, 5)
post_p 0.77 (0.67, 0.87) 0.61 (0.54, 0.79) 0.63 (0.54, 0.77) 0.56 (0.51, 0.68) 0.64 (0.57, 0.72) 0.55 (0.52, 0.66) 0.77 (0.74, 0.88) 0.71 (0.57, 0.88)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.1 (0.059, 0.142) 0.044 (0, 0.09) 0.042 (0, 0.091) 0 (0, 0.084) 0 (0, 0.046) 0.074 (0, 0.103) 0.024 (0, 0.054) 0 (0, 0.04)
Niraparib count 5 5 5 5 5 5 5 5
time 15 (10, 17) 15 (10, 17) 15 (10, 17) 15 (10, 17) 15 (10, 17) 15 (10, 17) 15 (10, 17) 15 (10, 17)
n 9 (9, 20) 4 (1, 8) 6 (3, 7) 2 (1, 6) 3 (2, 5) 3 (2, 4) 3 (2, 4) 2 (1, 4)
post_p 0.74 (0.72, 0.84) 0.62 (0.55, 0.7) 0.78 (0.6, 1) 0.6 (0.57, 0.69) 0.6 (0.56, 0.8) 0.62 (0.56, 0.83) 0.7 (0.63, 0.79) 0.7 (0.62, 0.81)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.094 (0.072, 0.1) 0.076 (0.021, 0.086) 0 (0, 0.01) 0.038 (0, 0.082) 0.043 (0, 0.221) 0.027 (0, 0.094) 0 (0, 0.065) 0 (0, 0.02)
DRD+ Carboplatin count 164 164 164 164 164 164 164 164
time 18 (11, 34) 18 (11, 34) 18 (11, 34) 18 (11, 34) 18 (11, 34) 18 (11, 34) 18 (11, 34) 18 (11, 34)
n 8 (3, 19) 8 (3, 18) 5 (1, 11) 5 (1, 11) 5 (1, 12) 4 (1, 11) 4 (1, 12) 4 (1, 11)
post_p 0.8 (0.57, 0.96) 0.73 (0.54, 0.86) 0.76 (0.56, 0.94) 0.74 (0.54, 0.91) 0.82 (0.56, 0.97) 0.7 (0.53, 0.9) 0.78 (0.56, 0.96) 0.72 (0.53, 0.91)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.028 (0, 0.056) 0.023 (0, 0.043) 0.026 (0, 0.074) 0.023 (0, 0.062) 0.031 (0, 0.072) 0.025 (0, 0.066) 0.031 (0, 0.076) 0.025 (0, 0.059)
Niraparib count 172 172 172 172 172 172 172 172
time 20 (11, 32) 20 (11, 32) 20 (11, 32) 20 (11, 32) 20 (11, 32) 20 (11, 32) 20 (11, 32) 20 (11, 32)
n 8 (3, 17) 8 (3, 18) 5 (1, 10) 5 (1, 10) 4 (1, 10) 4 (2, 12) 4 (2, 10) 4 (1, 11)
post_p 0.79 (0.62, 0.94) 0.73 (0.55, 0.88) 0.79 (0.55, 0.96) 0.72 (0.53, 0.9) 0.78 (0.53, 0.97) 0.71 (0.53, 0.91) 0.77 (0.55, 0.95) 0.7 (0.55, 0.91)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.028 (0, 0.055) 0.022 (0, 0.042) 0.029 (0, 0.076) 0.025 (0, 0.059) 0.025 (0, 0.079) 0.025 (0, 0.069) 0.034 (0, 0.079) 0.026 (0, 0.063)
TEfus+ Hormone_therapies count 1 1 1 1 1 1 1 1
time 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16) 16 (16, 16)
n 1 (1, 1) 10 (10, 10) 2 (2, 2) 1 (1, 1) 3 (3, 3) 6 (6, 6) 1 (1, 1) 1 (1, 1)
post_p 0.62 (0.62, 0.62) 0.75 (0.75, 0.75) 0.67 (0.67, 0.67) 0.62 (0.62, 0.62) 0.56 (0.56, 0.56) 0.78 (0.78, 0.78) NA (NA, NA) 0.6 (0.6, 0.6)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0 (0, 0) 0.058 (0.058, 0.058) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.113 (0.113, 0.113) 0.298 (0.298, 0.298) 0 (0, 0)
Taxel_therapies count 197 197 197 197 197 197 197 197
time 14 (9, 30) 14 (9, 30) 14 (9, 30) 14 (9, 30) 14 (9, 30) 14 (9, 30) 14 (9, 30) 14 (9, 30)
n 6 (2, 17) 17 (9, 39) 3 (1, 10) 2 (0, 6) 6 (2, 15) 5 (2, 14) 2 (0, 6) 2 (0, 6)
post_p 0.73 (0.55, 0.9) 0.93 (0.75, 1) 0.57 (0.51, 0.79) 0.63 (0.52, 0.87) 0.84 (0.61, 0.98) 0.79 (0.58, 0.98) 0.6 (0.51, 0.79) 0.6 (0.52, 0.82)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.025 (0, 0.049) 0.035 (0.014, 0.065) 0 (0, 0.041) 0 (0, 0.051) 0.029 (0, 0.058) 0.028 (0, 0.074) 0 (0, 0.06) 0 (0, 0.053)
Carboplatin count 3 3 3 3 3 3 3 3
time 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13)
n 0 (0, 3) 4 (2, 6) 4 (3, 5) 3 (1, 6) 3 (2, 3) 1 (0, 4) 4 (2, 5) 3 (2, 6)
post_p 0.5 (0.5, 0.5) 0.62 (0.56, 0.82) 0.79 (0.64, 0.82) 0.58 (0.55, 0.69) 0.6 (0.52, 0.67) 0.56 (0.52, 0.6) 0.62 (0.58, 0.64) 0.62 (0.59, 0.81)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0.032 (0.006, 0.056) 0 (0, 0.067) 0 (0, 0.076) 0.087 (0.017, 0.119) 0.03 (0.006, 0.055) 0 (0, 0.022) 0 (0, 0.012)
Niraparib count 2 2 2 2 2 2 2 2
time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
n 0 (0, 1) 6 (4, 8) 6 (5, 6) 6 (5, 8) 0 (0, 1) 2 (1, 2) 4 (3, 5) 3 (2, 4)
post_p 0.59 (0.59, 0.59) 0.79 (0.75, 0.83) 0.73 (0.71, 0.76) 0.72 (0.65, 0.79) 0.55 (0.55, 0.55) 0.55 (0.54, 0.56) 0.64 (0.6, 0.67) 0.6 (0.58, 0.63)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0.016 (0.003, 0.029) 0 (0, 0) 0.017 (0.003, 0.031) 0 (0, 0) 0.072 (0.014, 0.129) 0.022 (0.004, 0.039) 0 (0, 0)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4)
n 10 (10, 10) 2 (2, 2) 7 (7, 7) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 2) 2 (2, 2) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
post_p 0.36 (0.36, 0.36) 0.48 (0.48, 0.48) 0.17 (0.17, 0.17) 0.49 (0.49, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.43 (0.43, 0.43) 0.37 (0.37, 0.37) NA (NA, NA) 0.35 (0.35, 0.35) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.129 (0.129, 0.129) 0 (0, 0) 0.293 (0.293, 0.293) 0.247 (0.247, 0.247) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.435 (0.435, 0.435) 0.127 (0.127, 0.127) NA (NA, NA) 5.011 (5.011, 5.011) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
TP53- & AR- count 3 3 3 3
time 9 (8, 9) 9 (8, 9) 9 (8, 9) 9 (8, 9)
n 24 (24, 26) 5 (3, 7) 0 (0, 0) 0 (0, 3)
post_p 0.4 (0.36, 0.47) 0.46 (0.44, 0.48) NA (NA, NA) 0.35 (0.35, 0.35)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.099 (0.092, 0.101) 0.063 (0.056, 0.073) NA (NA, NA) 0 (0, 0)
Taxel_therapies count 86 86 86 86
time 21 (12, 32) 21 (12, 32) 21 (12, 32) 21 (12, 32)
n 15 (7, 36) 7 (3, 15) 4 (1, 7) 4 (0, 8)
post_p 0.13 (0.02, 0.38) 0.44 (0.28, 0.49) 0.29 (0.1, 0.4) 0.42 (0.18, 0.49)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.153 (0.107, 0.25) 0.069 (0.046, 0.132) 0.198 (0.08, 1.121) 0.066 (0.036, 0.209)
Carboplatin count 43 43 43 43
time 17 (12, 30) 17 (12, 30) 17 (12, 30) 17 (12, 30)
n 18 (8, 40) 4 (1, 7) 5 (2, 10) 6 (2, 8)
post_p 0.18 (0.02, 0.39) 0.26 (0.1, 0.39) 0.42 (0.19, 0.49) 0.38 (0.22, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.156 (0.114, 0.204) 0.198 (0.07, 0.82) 0.087 (0.049, 0.345) 0.057 (0.037, 0.122)
Niraparib count 51 51 51 51
time 19 (13, 32) 19 (13, 32) 19 (13, 32) 19 (13, 32)
n 17 (5, 39) 4 (1, 12) 6 (2, 12) 7 (3, 13)
post_p 0.1 (0.01, 0.28) 0.18 (0.06, 0.4) 0.36 (0.19, 0.49) 0.39 (0.22, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.179 (0.129, 0.341) 0.204 (0.093, 0.753) 0.09 (0.051, 0.23) 0.057 (0.037, 0.099)
TP53+ Hormone_therapies count 275 275 275 275 275 275 275 275
time 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32)
n 15 (7, 35) 6 (3, 13) 2 (0, 5) 2 (0, 4) 3 (1, 8) 3 (1, 8) 2 (0, 4) 2 (0, 4)
post_p 0.33 (0.1, 0.46) 0.22 (0.07, 0.44) 0.34 (0.21, 0.47) 0.3 (0.16, 0.47) 0.37 (0.19, 0.48) 0.32 (0.16, 0.47) 0.34 (0.2, 0.47) 0.31 (0.15, 0.44)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.18 (0.14, 0.284) 0.177 (0.107, 0.399) 0.201 (0.1, 0.772) 0.202 (0.07, 0.793) 0.242 (0.143, 0.711) 0.184 (0.107, 0.611) 0.227 (0.104, 0.936) 0.222 (0.088, 0.93)
DRD+ count 33 33 33 33 33 33 33 33
time 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35) 28 (22, 35)
n 4 (0, 8) 4 (1, 9) 2 (0, 8) 3 (1, 5) 3 (2, 6) 4 (1, 6) 3 (1, 4) 3 (1, 5)
post_p 0.36 (0.29, 0.5) 0.41 (0.17, 0.48) 0.32 (0.2, 0.44) 0.29 (0.18, 0.4) 0.28 (0.18, 0.46) 0.25 (0.16, 0.39) 0.36 (0.19, 0.46) 0.24 (0.08, 0.38)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.094 (0.06, 0.158) 0.076 (0.039, 0.122) 0.181 (0.124, 0.626) 0.189 (0.117, 0.59) 0.237 (0.1, 0.514) 0.181 (0.107, 0.643) 0.209 (0.094, 0.445) 0.205 (0.108, 0.722)
Taxel_therapies count 5 5 5 5 5 5 5 5
time 28 (22, 34) 28 (22, 34) 28 (22, 34) 28 (22, 34) 28 (22, 34) 28 (22, 34) 28 (22, 34) 28 (22, 34)
n 5 (3, 11) 3 (1, 10) 4 (1, 7) 4 (1, 5) 2 (1, 4) 0 (0, 5) 2 (1, 4) 3 (2, 8)
post_p 0.22 (0.08, 0.3) 0.28 (0.18, 0.42) 0.29 (0.16, 0.41) 0.44 (0.36, 0.48) 0.2 (0.18, 0.27) 0.41 (0.35, 0.47) 0.31 (0.27, 0.42) 0.41 (0.29, 0.45)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.18 (0.114, 0.297) 0.101 (0.063, 0.159) 0.229 (0.099, 0.732) 0.071 (0.055, 0.094) 0.325 (0.18, 1.032) 0.062 (0.042, 0.082) 0.151 (0.127, 0.47) 0.099 (0.05, 0.113)
TEfus+ Hormone_therapies count 103 103 103 103 103 103 103 103
time 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34)
n 5 (2, 15) 7 (3, 14) 3 (1, 10) 2 (0, 5) 4 (2, 8) 4 (1, 8) 2 (1, 5) 2 (1, 4)
post_p 0.41 (0.22, 0.49) 0.21 (0.08, 0.41) 0.39 (0.24, 0.48) 0.3 (0.14, 0.44) 0.29 (0.13, 0.46) 0.31 (0.13, 0.45) 0.28 (0.17, 0.42) 0.31 (0.16, 0.43)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.082 (0.053, 0.162) 0.173 (0.11, 0.407) 0.069 (0.039, 0.19) 0.193 (0.09, 0.622) 0.213 (0.097, 0.561) 0.187 (0.108, 0.545) 0.192 (0.088, 0.809) 0.199 (0.09, 0.79)
Carboplatin count 5 5 5 5 5 5 5 5
time 19 (15, 21) 19 (15, 21) 19 (15, 21) 19 (15, 21) 19 (15, 21) 19 (15, 21) 19 (15, 21) 19 (15, 21)
n 2 (2, 6) 5 (3, 9) 6 (5, 9) 4 (0, 5) 2 (0, 6) 3 (3, 11) 4 (2, 8) 3 (2, 5)
post_p 0.39 (0.18, 0.47) 0.22 (0.09, 0.39) 0.37 (0.32, 0.39) 0.3 (0.18, 0.4) 0.27 (0.2, 0.44) 0.34 (0.23, 0.43) 0.46 (0.3, 0.5) 0.41 (0.23, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.11 (0.064, 0.46) 0.224 (0.153, 0.356) 0.047 (0.03, 0.055) 0.1 (0.073, 0.125) 0.196 (0.091, 0.473) 0.176 (0.152, 0.315) 0.076 (0.032, 0.229) 0.099 (0.068, 0.238)
Niraparib count 5 5 5 5 5 5 5 5
time 29 (14, 34) 29 (14, 34) 29 (14, 34) 29 (14, 34) 29 (14, 34) 29 (14, 34) 29 (14, 34) 29 (14, 34)
n 6 (5, 20) 6 (3, 7) 4 (3, 17) 4 (3, 6) 3 (1, 3) 2 (1, 6) 2 (1, 5) 2 (1, 7)
post_p 0.13 (0.02, 0.23) 0.13 (0.07, 0.3) 0.47 (0.37, 0.49) 0.36 (0.29, 0.46) 0.27 (0.18, 0.44) 0.35 (0.25, 0.39) 0.3 (0.22, 0.47) 0.39 (0.29, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.154 (0.135, 0.188) 0.249 (0.155, 0.414) 0.06 (0.041, 0.069) 0.059 (0.048, 0.155) 0.304 (0.108, 0.478) 0.208 (0.147, 0.571) 0.158 (0.103, 0.542) 0.096 (0.078, 0.102)