several treatments more effective in distinctive signatures: (Hormone_therapies, TP53- & AR-); (Taxel_therapies, TEfus); (Carboplatin, DRD+)
By subgroup:
| subtype | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| —+ | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| –+- | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| –++ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| -+– | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 6.3, median = 4.5 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 0.71, hr = 1.43 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 25, median = 18 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 2.85, hr = 0.33 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -++- | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| -+++ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| +— | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| +–+ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| +-+- | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| +-++ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | |
| ++– | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| ++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| +++- | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 6.3, median = 4.5 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 0.71, hr = 1.43 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| ++++ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 25, median = 18 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 2.85, hr = 0.33 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 |
By signature:
| signature | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| all | param | scale = 0.112, shape = 1.05 | scale = 0.129, shape = 1.05 | scale = 0.099, shape = 1.05 | scale = 0.098, shape = 1.05 | scale = 0.098, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 7.6, median = 5.5 | mean = 9.9, median = 7.1 | mean = 10, median = 7.2 | mean = 10, median = 7.2 | |
| effect | af = 1, hr = 1 | af = 0.87, hr = 1.16 | af = 1.13, hr = 0.88 | af = 1.14, hr = 0.87 | af = 1.14, hr = 0.87 | |
| TP53- & AR- | param | scale = 0.112, shape = 1.05 | scale = 0.043, shape = 1.05 | scale = 0.099, shape = 1.05 | scale = 0.098, shape = 1.05 | scale = 0.098, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 22.6, median = 16.3 | mean = 9.9, median = 7.1 | mean = 10, median = 7.2 | mean = 10, median = 7.2 | |
| effect | af = 1, hr = 1 | af = 2.58, hr = 0.37 | af = 1.13, hr = 0.88 | af = 1.14, hr = 0.87 | af = 1.14, hr = 0.87 | |
| TP53+ | param | scale = 0.112, shape = 1.05 | scale = 0.157, shape = 1.05 | scale = 0.099, shape = 1.05 | scale = 0.098, shape = 1.05 | scale = 0.098, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 6.3, median = 4.5 | mean = 9.9, median = 7.1 | mean = 10, median = 7.2 | mean = 10, median = 7.2 | |
| effect | af = 1, hr = 1 | af = 0.71, hr = 1.43 | af = 1.13, hr = 0.88 | af = 1.14, hr = 0.87 | af = 1.14, hr = 0.87 | |
| DRD+ | param | scale = 0.112, shape = 1.05 | scale = 0.129, shape = 1.05 | scale = 0.099, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.037, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 7.6, median = 5.5 | mean = 9.9, median = 7.1 | mean = 26.6, median = 19.1 | mean = 26.6, median = 19.1 | |
| effect | af = 1, hr = 1 | af = 0.87, hr = 1.16 | af = 1.13, hr = 0.88 | af = 3.03, hr = 0.31 | af = 3.03, hr = 0.31 | |
| TEfus+ | param | scale = 0.112, shape = 1.05 | scale = 0.129, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.098, shape = 1.05 | scale = 0.098, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 7.6, median = 5.5 | mean = 25, median = 18 | mean = 10, median = 7.2 | mean = 10, median = 7.2 | |
| effect | af = 1, hr = 1 | af = 0.87, hr = 1.16 | af = 2.85, hr = 0.33 | af = 1.14, hr = 0.87 | af = 1.14, hr = 0.87 |
|
|
|
|
|
|
The overall error was 0.064.
The corresponding errors separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.010 0.030 0.012 0.014
The overall power was 0.894.
The corresponding power separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.646 0.394 0.328 0.344
| signature | var | Control | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| all | graduation | 0 | 8 | 5 | 0 | 2 |
| futility | 0 | 1 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 462 (431, 493) | 144 (85, 244) | 188 (103, 254) | 176 (116, 257) | 181 (121, 254) | |
| n_unique | 423 (398, 451) | 134 (78, 230) | 174 (92, 237) | 161 (105, 241) | 165 (110, 238) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 4 (4, 7) | 5 (4, 7) | NA (NA, NA) | 6 (5, 6) | |
| post_p | NA (NA, NA) | 0.89 (0.19, 1) | 0.99 (0.48, 1) | 0.92 (0.25, 1) | 0.86 (0.16, 1) | |
| rate | 0.094 (0.087, 0.102) | 0.079 (0.062, 0.101) | 0.071 (0.057, 0.091) | 0.08 (0.064, 0.099) | 0.081 (0.064, 0.103) | |
| TP53- & AR- | graduation | 0 | 323 | 2 | 1 | 2 |
| futility | 0 | 3 | 86 | 43 | 51 | |
| max_n | 0 | 106 | 8 | 35 | 32 | |
| n | 198 (179, 217) | 48 (26, 152) | 41 (24, 100) | 54 (27, 137) | 55 (27, 140) | |
| n_unique | 183 (164, 202) | 46 (25, 146) | 36 (20, 95) | 49 (24, 132) | 48 (25, 131) | |
| time_trial | 36 (36, 36) | 12 (7, 36) | 36 (23, 36) | 36 (36, 36) | 36 (34, 36) | |
| time_stop | NA (NA, NA) | 9 (6, 18) | 20 (12, 32) | 18 (12, 29) | 19 (13, 32) | |
| post_p | NA (NA, NA) | 1 (0.95, 1) | 0.4 (0.01, 0.93) | 0.45 (0, 0.96) | 0.41 (0, 0.96) | |
| rate | 0.075 (0.067, 0.085) | 0.043 (0.033, 0.052) | 0.08 (0.053, 0.121) | 0.076 (0.05, 0.117) | 0.079 (0.051, 0.119) | |
| TP53+ | graduation | 0 | 1 | 25 | 7 | 5 |
| futility | 0 | 275 | 0 | 0 | 0 | |
| max_n | 0 | 2 | 29 | 16 | 13 | |
| n | 200 (180, 222) | 51 (27, 94) | 108 (47, 144) | 82 (50, 121) | 84 (52, 123) | |
| n_unique | 183 (163, 203) | 47 (25, 87) | 100 (44, 133) | 75 (45, 113) | 77 (46, 115) | |
| time_trial | 36 (36, 36) | 32 (13, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 20 (12, 32) | 10 (7, 18) | 10 (8, 14) | 15 (10, 17) | |
| post_p | NA (NA, NA) | 0.02 (0, 0.15) | 1 (0.85, 1) | 0.95 (0.46, 1) | 0.92 (0.46, 1) | |
| rate | 0.113 (0.1, 0.126) | 0.163 (0.137, 0.208) | 0.067 (0.05, 0.09) | 0.085 (0.063, 0.111) | 0.088 (0.064, 0.112) | |
| DRD+ | graduation | 0 | 0 | 0 | 164 | 172 |
| futility | 0 | 33 | 5 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 117 (100, 137) | 24 (14, 39) | 35 (19, 57) | 79 (30, 107) | 75 (31, 105) | |
| n_unique | 105 (89, 123) | 22 (12, 36) | 31 (17, 51) | 73 (28, 99) | 69 (28, 94) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (13, 36) | 36 (14, 36) | |
| time_stop | NA (NA, NA) | 28 (22, 35) | 28 (22, 34) | 18 (11, 34) | 20 (11, 32) | |
| post_p | NA (NA, NA) | 0.2 (0.02, 0.78) | 0.81 (0.24, 0.99) | 1 (1, 1) | 1 (1, 1) | |
| rate | 0.092 (0.078, 0.106) | 0.107 (0.072, 0.175) | 0.068 (0.048, 0.1) | 0.036 (0.028, 0.044) | 0.036 (0.029, 0.044) | |
| TEfus+ | graduation | 0 | 1 | 197 | 3 | 2 |
| futility | 0 | 103 | 0 | 5 | 5 | |
| max_n | 0 | 0 | 33 | 1 | 0 | |
| n | 170 (149, 189) | 35 (23, 58) | 112 (30, 144) | 63 (40, 98) | 62 (38, 98) | |
| n_unique | 153 (135, 172) | 32 (20, 54) | 102 (28, 133) | 57 (35, 89) | 56 (34, 89) | |
| time_trial | 36 (36, 36) | 36 (24, 36) | 36 (11, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 25 (16, 34) | 14 (9, 30) | 16 (12, 20) | 18 (10, 33) | |
| post_p | NA (NA, NA) | 0.07 (0, 0.46) | 1 (0.99, 1) | 0.7 (0.11, 0.98) | 0.7 (0.13, 0.98) | |
| rate | 0.075 (0.065, 0.086) | 0.103 (0.076, 0.143) | 0.038 (0.031, 0.045) | 0.067 (0.049, 0.094) | 0.066 (0.05, 0.089) |
| subtype | var | Control | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| —- | graduation | 0 | 332 | 93 | 44 | 55 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 106 | 8 | 35 | 32 | |
| n | 132 (115, 148) | 39 (21, 126) | 14 (7, 78) | 17 (7, 97) | 16 (6, 100) | |
| n_unique | 122 (107, 139) | 37 (20, 121) | 12 (6, 75) | 14 (5, 92) | 14 (5, 96) | |
| post_p | NA (NA, NA) | 1 (0.99, 1) | 0.04 (0, 0.18) | 0.03 (0, 0.14) | 0.03 (0, 0.16) | |
| rate | 0.084 (0.072, 0.097) | 0.043 (0.033, 0.053) | 0.173 (0.131, 0.277) | 0.168 (0.129, 0.294) | 0.168 (0.134, 0.296) | |
| —+ | graduation | 0 | 369 | 271 | 50 | 61 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 103 | 39 | 36 | 32 | |
| n | 23 (17, 31) | 5 (2, 17) | 13 (3, 25) | 5 (2, 18) | 5 (2, 16) | |
| n_unique | 21 (15, 28) | 5 (2, 16) | 12 (3, 23) | 4 (2, 16) | 4 (2, 14) | |
| post_p | NA (NA, NA) | 0.69 (0.32, 0.92) | 0.8 (0.42, 0.97) | 0.13 (0.01, 0.31) | 0.13 (0.03, 0.28) | |
| rate | 0.051 (0.035, 0.075) | 0.045 (0.021, 0.101) | 0.039 (0.022, 0.071) | 0.179 (0.107, 0.445) | 0.183 (0.107, 0.476) | |
| –+- | graduation | 0 | 285 | 29 | 7 | 7 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 2 | 29 | 16 | 13 | |
| n | 66 (53, 79) | 19 (8, 53) | 24 (6, 58) | 21 (5, 56) | 26 (6, 56) | |
| n_unique | 61 (47, 73) | 18 (7, 51) | 21 (5, 55) | 19 (5, 53) | 24 (6, 52) | |
| post_p | NA (NA, NA) | 0.33 (0.09, 0.76) | 0.34 (0.08, 0.79) | 0.29 (0.08, 0.75) | 0.34 (0.1, 0.73) | |
| rate | 0.146 (0.122, 0.173) | 0.17 (0.131, 0.277) | 0.168 (0.126, 0.31) | 0.173 (0.132, 0.335) | 0.17 (0.131, 0.297) | |
| –++ | graduation | 0 | 327 | 210 | 14 | 14 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 2 | 60 | 17 | 13 | |
| n | 49 (40, 60) | 6 (3, 15) | 40 (11, 55) | 8 (3, 32) | 8 (3, 30) | |
| n_unique | 45 (37, 56) | 5 (2, 14) | 37 (10, 52) | 7 (3, 30) | 7 (3, 28) | |
| post_p | NA (NA, NA) | 0.16 (0.06, 0.36) | 1 (0.94, 1) | 0.15 (0.03, 0.36) | 0.15 (0.03, 0.38) | |
| rate | 0.086 (0.067, 0.11) | 0.182 (0.119, 0.393) | 0.038 (0.027, 0.051) | 0.172 (0.113, 0.391) | 0.171 (0.112, 0.376) | |
| -+– | graduation | 0 | 341 | 97 | 198 | 221 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 104 | 8 | 32 | 31 | |
| n | 21 (15, 29) | 3 (0, 10) | 4 (2, 10) | 14 (4, 24) | 13 (4, 23) | |
| n_unique | 19 (13, 27) | 2 (0, 10) | 3 (1, 9) | 13 (4, 22) | 12 (4, 21) | |
| post_p | NA (NA, NA) | 0.68 (0.34, 0.92) | 0.2 (0.07, 0.4) | 0.91 (0.52, 0.99) | 0.89 (0.49, 0.99) | |
| rate | 0.085 (0.059, 0.127) | 0.047 (0.015, 0.134) | 0.181 (0.096, 0.584) | 0.035 (0.02, 0.069) | 0.038 (0.02, 0.074) | |
| -+-+ | graduation | 0 | 373 | 274 | 203 | 224 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 101 | 39 | 33 | 31 | |
| n | 21 (14, 29) | 3 (0, 10) | 6 (1, 16) | 11 (4, 24) | 12 (4, 23) | |
| n_unique | 19 (12, 26) | 2 (0, 9) | 5 (1, 14) | 10 (3, 22) | 10 (4, 22) | |
| post_p | NA (NA, NA) | 0.51 (0.27, 0.81) | 0.58 (0.27, 0.85) | 0.66 (0.27, 0.91) | 0.68 (0.3, 0.92) | |
| rate | 0.053 (0.035, 0.077) | 0.049 (0.017, 0.132) | 0.04 (0.018, 0.101) | 0.036 (0.02, 0.072) | 0.035 (0.02, 0.071) | |
| -++- | graduation | 0 | 298 | 33 | 166 | 176 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 2 | 29 | 12 | 13 | |
| n | 12 (7, 18) | 2 (1, 6) | 3 (1, 7) | 8 (2, 15) | 8 (2, 15) | |
| n_unique | 11 (7, 16) | 2 (0, 6) | 2 (1, 6) | 7 (2, 14) | 7 (2, 14) | |
| post_p | NA (NA, NA) | 0.35 (0.2, 0.59) | 0.34 (0.17, 0.58) | 0.93 (0.65, 1) | 0.91 (0.56, 1) | |
| rate | 0.15 (0.099, 0.226) | 0.184 (0.088, 0.696) | 0.179 (0.083, 0.635) | 0.037 (0.014, 0.085) | 0.037 (0.014, 0.097) | |
| -+++ | graduation | 0 | 334 | 213 | 173 | 180 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 2 | 60 | 13 | 13 | |
| n | 12 (8, 18) | 2 (1, 5) | 3 (0, 10) | 7 (2, 15) | 7 (2, 13) | |
| n_unique | 11 (7, 16) | 2 (0, 4) | 3 (0, 9) | 7 (2, 13) | 6 (2, 12) | |
| post_p | NA (NA, NA) | 0.29 (0.13, 0.42) | 0.67 (0.36, 0.93) | 0.78 (0.44, 0.96) | 0.77 (0.44, 0.96) | |
| rate | 0.085 (0.052, 0.14) | 0.2 (0.093, 0.679) | 0.041 (0, 0.152) | 0.037 (0.017, 0.085) | 0.038 (0.016, 0.086) | |
| +— | graduation | 0 | 9 | 5 | 0 | 2 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 21 (15, 28) | 8 (3, 20) | 11 (3, 21) | 7 (2, 18) | 7 (2, 17) | |
| n_unique | 19 (13, 25) | 7 (2, 18) | 9 (3, 19) | 7 (2, 17) | 7 (2, 16) | |
| post_p | NA (NA, NA) | 0.4 (0.16, 0.78) | 0.42 (0.15, 0.82) | 0.41 (0.17, 0.81) | 0.43 (0.19, 0.82) | |
| rate | 0.148 (0.109, 0.206) | 0.183 (0.112, 0.457) | 0.171 (0.113, 0.404) | 0.178 (0.108, 0.529) | 0.174 (0.106, 0.511) | |
| +–+ | graduation | 0 | 113 | 201 | 8 | 9 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 33 | 1 | 0 | |
| n | 18 (12, 25) | 4 (2, 11) | 13 (3, 23) | 4 (2, 11) | 4 (2, 12) | |
| n_unique | 16 (11, 23) | 4 (1, 9) | 12 (3, 21) | 4 (1, 10) | 4 (1, 11) | |
| post_p | NA (NA, NA) | 0.26 (0.12, 0.51) | 0.95 (0.66, 1) | 0.25 (0.11, 0.49) | 0.25 (0.11, 0.48) | |
| rate | 0.086 (0.056, 0.128) | 0.183 (0.098, 0.47) | 0.038 (0.02, 0.071) | 0.202 (0.102, 0.605) | 0.19 (0.1, 0.528) | |
| +-+- | graduation | 0 | 285 | 29 | 7 | 7 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 2 | 29 | 16 | 13 | |
| n | 16 (11, 23) | 5 (1, 14) | 7 (3, 18) | 6 (2, 16) | 6 (2, 16) | |
| n_unique | 15 (10, 22) | 4 (1, 13) | 6 (2, 16) | 6 (2, 15) | 6 (2, 14) | |
| post_p | NA (NA, NA) | 0.39 (0.2, 0.79) | 0.42 (0.17, 0.8) | 0.41 (0.19, 0.81) | 0.37 (0.18, 0.77) | |
| rate | 0.146 (0.105, 0.21) | 0.192 (0.11, 0.583) | 0.176 (0.114, 0.421) | 0.179 (0.106, 0.511) | 0.195 (0.115, 0.464) | |
| +-++ | graduation | 0 | 327 | 210 | 14 | 14 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 2 | 60 | 17 | 13 | |
| n | 18 (13, 25) | 4 (1, 10) | 12 (3, 22) | 4 (2, 12) | 5 (2, 13) | |
| n_unique | 16 (11, 22) | 3 (1, 9) | 11 (3, 20) | 4 (1, 11) | 4 (2, 12) | |
| post_p | NA (NA, NA) | 0.28 (0.12, 0.51) | 0.95 (0.68, 1) | 0.25 (0.1, 0.47) | 0.25 (0.1, 0.48) | |
| rate | 0.087 (0.056, 0.134) | 0.183 (0.106, 0.516) | 0.039 (0.023, 0.07) | 0.189 (0.106, 0.472) | 0.181 (0.105, 0.453) | |
| ++– | graduation | 0 | 42 | 10 | 164 | 174 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 12 (8, 17) | 3 (1, 6) | 3 (1, 7) | 8 (2, 15) | 8 (2, 15) | |
| n_unique | 11 (7, 16) | 3 (1, 6) | 3 (1, 6) | 7 (2, 14) | 7 (2, 14) | |
| post_p | NA (NA, NA) | 0.34 (0.18, 0.56) | 0.33 (0.18, 0.59) | 0.94 (0.6, 1) | 0.93 (0.61, 1) | |
| rate | 0.148 (0.1, 0.242) | 0.193 (0.094, 0.576) | 0.192 (0.094, 0.719) | 0.037 (0.016, 0.085) | 0.038 (0.015, 0.092) | |
| ++-+ | graduation | 0 | 132 | 205 | 171 | 178 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 33 | 1 | 0 | |
| n | 12 (8, 18) | 3 (1, 6) | 4 (1, 11) | 7 (2, 15) | 7 (2, 13) | |
| n_unique | 11 (7, 16) | 2 (1, 5) | 3 (1, 10) | 7 (2, 14) | 6 (2, 12) | |
| post_p | NA (NA, NA) | 0.25 (0.12, 0.44) | 0.7 (0.38, 0.93) | 0.77 (0.44, 0.96) | 0.77 (0.37, 0.96) | |
| rate | 0.086 (0.051, 0.144) | 0.185 (0.096, 0.59) | 0.04 (0.011, 0.109) | 0.038 (0.017, 0.088) | 0.037 (0.016, 0.117) | |
| +++- | graduation | 0 | 298 | 33 | 166 | 176 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 2 | 29 | 12 | 13 | |
| n | 12 (7, 18) | 2 (1, 6) | 3 (1, 7) | 8 (2, 16) | 8 (2, 14) | |
| n_unique | 11 (6, 16) | 2 (0, 5) | 3 (1, 7) | 7 (2, 14) | 7 (2, 13) | |
| post_p | NA (NA, NA) | 0.34 (0.2, 0.56) | 0.34 (0.17, 0.59) | 0.93 (0.59, 1) | 0.92 (0.59, 1) | |
| rate | 0.149 (0.102, 0.233) | 0.206 (0.097, 0.747) | 0.186 (0.091, 0.588) | 0.037 (0.015, 0.089) | 0.037 (0.015, 0.087) | |
| ++++ | graduation | 0 | 334 | 213 | 173 | 180 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 2 | 60 | 13 | 13 | |
| n | 12 (8, 18) | 2 (1, 5) | 4 (0, 11) | 7 (2, 15) | 7 (2, 14) | |
| n_unique | 11 (7, 16) | 2 (0, 5) | 3 (0, 10) | 6 (2, 13) | 6 (2, 13) | |
| post_p | NA (NA, NA) | 0.27 (0.13, 0.41) | 0.69 (0.36, 0.92) | 0.76 (0.41, 0.96) | 0.77 (0.47, 0.96) | |
| rate | 0.089 (0.054, 0.144) | 0.215 (0.101, 0.71) | 0.042 (0.011, 0.145) | 0.038 (0.018, 0.091) | 0.038 (0.014, 0.085) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 8 | 5 | 2 | |
| time_stop | 4 (4, 7) | 5 (4, 7) | 6 (5, 6) | ||
| n_trt | 30 (25, 50) | 27 (26, 41) | 33 (27, 39) | ||
| n_control | 52 (46, 72) | 60 (45, 83) | 65 (63, 67) | ||
| post_p | 0.93 (0.87, 0.97) | 0.89 (0.87, 0.96) | 0.94 (0.91, 0.98) | ||
| order | 1 (1, 1.3) | 1 (1, 1) | 1 (1, 1) | ||
| TP53- & AR- | count | 323 | 2 | 1 | 2 |
| time_stop | 9 (6, 19) | 13 (13, 13) | 20 (20, 20) | 12 (10, 13) | |
| n_trt | 34 (26, 75) | 31 (27, 35) | 45 (45, 45) | 26 (25, 26) | |
| n_control | 42 (28, 94) | 54 (51, 57) | 96 (96, 96) | 55 (53, 57) | |
| post_p | 0.94 (0.87, 1) | 0.95 (0.92, 0.98) | 0.95 (0.95, 0.95) | 0.97 (0.95, 0.98) | |
| order | 1 (1, 2) | 2 (2, 2) | 3 (3, 3) | 2.5 (2.1, 2.9) | |
| TP53+ | count | 1 | 25 | 7 | 5 |
| time_stop | 7 (7, 7) | 10 (7, 18) | 10 (8, 14) | 15 (10, 17) | |
| n_trt | 26 (26, 26) | 37 (29, 55) | 27 (26, 40) | 34 (30, 46) | |
| n_control | 33 (33, 33) | 53 (31, 93) | 51 (41, 73) | 76 (49, 96) | |
| post_p | 0.88 (0.88, 0.88) | 0.98 (0.92, 1) | 0.98 (0.95, 0.99) | 1 (0.96, 1) | |
| order | 1 (1, 1) | 2 (1, 2) | 1 (1, 2.4) | 2 (1, 2) | |
| DRD+ | count | 164 | 172 | ||
| time_stop | 18 (11, 34) | 20 (11, 32) | |||
| n_trt | 39 (26, 88) | 42 (26, 84) | |||
| n_control | 50 (28, 105) | 56 (29, 115) | |||
| post_p | 1 (0.98, 1) | 1 (0.97, 1) | |||
| order | 2 (1, 3) | 2 (1, 3) | |||
| TEfus+ | count | 1 | 197 | 3 | 2 |
| time_stop | 16 (16, 16) | 14 (9, 30) | 12 (11, 13) | 10 (10, 10) | |
| n_trt | 25 (25, 25) | 40 (27, 104) | 25 (25, 26) | 28 (26, 30) | |
| n_control | 62 (62, 62) | 55 (33, 138) | 49 (41, 60) | 49 (42, 56) | |
| post_p | 0.87 (0.87, 0.87) | 0.99 (0.93, 1) | 0.96 (0.94, 0.97) | 0.98 (0.97, 0.98) | |
| order | 3 (3, 3) | 2 (1, 3) | 2 (1.2, 2) | 2 (2, 2) |
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 1 | |||
| time_stop | 4 (4, 4) | ||||
| n_trt | 26 (26, 26) | ||||
| n_control | 52 (52, 52) | ||||
| post_p | 0.06 (0.06, 0.06) | ||||
| order | 1 (1, 1) | ||||
| TP53- & AR- | count | 3 | 86 | 43 | 51 |
| time_stop | 9 (8, 9) | 21 (12, 32) | 17 (12, 30) | 19 (13, 32) | |
| n_trt | 31 (28, 34) | 30 (25, 58) | 28 (25, 61) | 32 (25, 65) | |
| n_control | 37 (31, 37) | 106 (52, 174) | 90 (57, 155) | 96 (56, 180) | |
| post_p | 0.27 (0.26, 0.28) | 0.11 (0.01, 0.26) | 0.1 (0.01, 0.26) | 0.09 (0.01, 0.24) | |
| order | 1 (1, 1) | 1 (1, 2) | 1 (1, 2.8) | 1 (1, 3) | |
| TP53+ | count | 275 | |||
| time_stop | 20 (12, 32) | ||||
| n_trt | 36 (26, 67) | ||||
| n_control | 101 (54, 169) | ||||
| post_p | 0.02 (0, 0.1) | ||||
| order | 1 (1, 2) | ||||
| DRD+ | count | 33 | 5 | ||
| time_stop | 28 (22, 35) | 28 (22, 34) | |||
| n_trt | 26 (25, 31) | 27 (25, 36) | |||
| n_control | 81 (56, 113) | 92 (64, 113) | |||
| post_p | 0.05 (0.01, 0.18) | 0.08 (0.03, 0.16) | |||
| order | 2 (1, 3) | 2 (1.4, 2.6) | |||
| TEfus+ | count | 103 | 5 | 5 | |
| time_stop | 25 (16, 34) | 19 (15, 21) | 29 (14, 34) | ||
| n_trt | 30 (25, 53) | 27 (26, 48) | 31 (25, 63) | ||
| n_control | 108 (61, 156) | 72 (60, 83) | 137 (60, 154) | ||
| post_p | 0.02 (0, 0.11) | 0.08 (0.01, 0.26) | 0.03 (0.01, 0.14) | ||
| order | 2 (1, 3) | 2 (1, 2.6) | 3 (1.4, 3.6) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
| time | 4 (4, 7) | 4 (4, 7) | 4 (4, 7) | 4 (4, 7) | 4 (4, 7) | 4 (4, 7) | 4 (4, 7) | 4 (4, 7) | 4 (4, 7) | 4 (4, 7) | 4 (4, 7) | 4 (4, 7) | 4 (4, 7) | 4 (4, 7) | 4 (4, 7) | 4 (4, 7) | ||
| n | 16 (10, 22) | 2 (1, 5) | 8 (4, 12) | 1 (0, 4) | 0 (0, 1) | 0 (0, 3) | 0 (0, 0) | 0 (0, 1) | 1 (0, 2) | 2 (0, 2) | 0 (0, 2) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | ||
| post_p | 0.85 (0.75, 0.92) | 0.58 (0.53, 0.66) | 0.72 (0.63, 0.79) | 0.53 (0.51, 0.57) | 0.56 (0.52, 0.61) | 0.54 (0.52, 0.55) | 0.6 (0.6, 0.6) | 0.55 (0.55, 0.55) | 0.59 (0.53, 0.63) | 0.6 (0.51, 0.68) | 0.67 (0.63, 0.71) | 0.53 (0.52, 0.54) | NA (NA, NA) | 0.5 (0.5, 0.5) | 0.63 (0.54, 0.72) | NA (NA, NA) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.022 (0, 0.044) | 0 (0, 0.59) | 0.094 (0.025, 0.13) | 0 (0, 0.055) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.084) | 0 (0, 0.102) | 0 (0, 0.061) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0.485) | 0.175 (0.175, 0.175) | ||
| Taxel_therapies | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |
| time | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | 5 (4, 7) | ||
| n | 5 (4, 8) | 5 (1, 8) | 3 (3, 6) | 6 (5, 12) | 0 (0, 0) | 0 (0, 1) | 0 (0, 2) | 0 (0, 2) | 1 (1, 3) | 3 (0, 3) | 1 (1, 4) | 1 (0, 3) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | ||
| post_p | 0.59 (0.52, 0.63) | 0.58 (0.55, 0.79) | 0.59 (0.52, 0.7) | 0.68 (0.63, 0.77) | NA (NA, NA) | 0.53 (0.51, 0.54) | 0.55 (0.54, 0.56) | 0.59 (0.53, 0.65) | 0.66 (0.52, 0.75) | 0.6 (0.58, 0.69) | 0.56 (0.53, 0.61) | 0.67 (0.66, 0.72) | NA (NA, NA) | 0.5 (0.5, 0.5) | NA (NA, NA) | NA (NA, NA) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.056 (0.045, 0.071) | 0 (0, 0.016) | 0.129 (0.093, 0.164) | 0 (0, 0.044) | NA (NA, NA) | 0 (0, 0) | 0.181 (0.036, 0.325) | 0 (0, 0) | 0 (0, 0.178) | 0 (0, 0.053) | 0 (0, 0.261) | 0 (0, 0.036) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | ||
| Niraparib | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |
| time | 6 (5, 6) | 6 (5, 6) | 6 (5, 6) | 6 (5, 6) | 6 (5, 6) | 6 (5, 6) | 6 (5, 6) | 6 (5, 6) | 6 (5, 6) | 6 (5, 6) | 6 (5, 6) | 6 (5, 6) | 6 (5, 6) | 6 (5, 6) | 6 (5, 6) | 6 (5, 6) | ||
| n | 1 (0, 2) | 2 (1, 4) | 4 (1, 6) | 2 (0, 3) | 4 (2, 6) | 6 (5, 6) | 4 (4, 4) | 2 (0, 3) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | 2 (2, 3) | 2 (0, 3) | 2 (0, 3) | 4 (2, 5) | ||
| post_p | 0.52 (0.52, 0.52) | 0.52 (0.52, 0.52) | 0.54 (0.54, 0.54) | 0.52 (0.52, 0.52) | 0.52 (0.52, 0.53) | 0.55 (0.55, 0.56) | 0.64 (0.59, 0.69) | 0.54 (0.54, 0.54) | NA (NA, NA) | 0.6 (0.6, 0.6) | NA (NA, NA) | 0.57 (0.57, 0.57) | 0.62 (0.6, 0.63) | 0.64 (0.64, 0.64) | 0.59 (0.59, 0.59) | 0.7 (0.56, 0.85) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0 (0, 0) | 0 (0, 0) | 0.054 (0.054, 0.054) | 0 (0, 0) | 0.031 (0.006, 0.055) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0.085 (0.017, 0.154) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| TP53- & AR- | Hormone_therapies | count | 323 | 323 | 323 | 323 | ||||||||||||
| time | 9 (6, 19) | 9 (6, 19) | 9 (6, 19) | 9 (6, 19) | ||||||||||||||
| n | 28 (21, 63) | 4 (2, 9) | 1 (0, 4) | 1 (0, 5) | ||||||||||||||
| post_p | 0.95 (0.84, 1) | 0.65 (0.52, 0.81) | 0.57 (0.51, 0.75) | 0.56 (0.51, 0.71) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.036 (0.014, 0.056) | 0 (0, 0.066) | 0 (0, 0.06) | 0 (0, 0.036) | ||||||||||||||
| Taxel_therapies | count | 2 | 2 | 2 | 2 | |||||||||||||
| time | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | ||||||||||||||
| n | 17 (15, 19) | 8 (6, 9) | 2 (1, 2) | 5 (3, 7) | ||||||||||||||
| post_p | 0.74 (0.71, 0.76) | 0.93 (0.9, 0.96) | 0.57 (0.55, 0.59) | 0.71 (0.62, 0.8) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.084 (0.083, 0.086) | 0.022 (0.021, 0.022) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| Carboplatin | count | 1 | 1 | 1 | 1 | |||||||||||||
| time | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | 20 (20, 20) | ||||||||||||||
| n | 28 (28, 28) | 2 (2, 2) | 4 (4, 4) | 11 (11, 11) | ||||||||||||||
| post_p | 0.76 (0.76, 0.76) | 0.6 (0.6, 0.6) | 0.74 (0.74, 0.74) | 0.79 (0.79, 0.79) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.076 (0.076, 0.076) | 0 (0, 0) | 0.039 (0.039, 0.039) | 0.014 (0.014, 0.014) | ||||||||||||||
| Niraparib | count | 2 | 2 | 2 | 2 | |||||||||||||
| time | 12 (10, 13) | 12 (10, 13) | 12 (10, 13) | 12 (10, 13) | ||||||||||||||
| n | 12 (12, 12) | 0 (0, 0) | 10 (8, 12) | 4 (2, 6) | ||||||||||||||
| post_p | 0.74 (0.72, 0.75) | NA (NA, NA) | 0.85 (0.79, 0.9) | 0.63 (0.54, 0.73) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.039 (0.035, 0.043) | NA (NA, NA) | 0.011 (0.002, 0.02) | 0 (0, 0) | ||||||||||||||
| TP53+ | Hormone_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| time | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | ||||||||||
| n | 14 (14, 14) | 5 (5, 5) | 1 (1, 1) | 1 (1, 1) | 4 (4, 4) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| post_p | 0.79 (0.79, 0.79) | 0.66 (0.66, 0.66) | 0.56 (0.56, 0.56) | 0.53 (0.53, 0.53) | 0.65 (0.65, 0.65) | 0.66 (0.66, 0.66) | NA (NA, NA) | NA (NA, NA) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.077 (0.077, 0.077) | 0.082 (0.082, 0.082) | 0 (0, 0) | 0 (0, 0) | 0.053 (0.053, 0.053) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | ||||||||||
| Taxel_therapies | count | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | |||||||||
| time | 10 (7, 18) | 10 (7, 18) | 10 (7, 18) | 10 (7, 18) | 10 (7, 18) | 10 (7, 18) | 10 (7, 18) | 10 (7, 18) | ||||||||||
| n | 12 (5, 21) | 14 (6, 22) | 1 (0, 3) | 1 (0, 4) | 4 (2, 6) | 4 (1, 10) | 0 (0, 3) | 1 (0, 3) | ||||||||||
| post_p | 0.76 (0.7, 0.88) | 0.84 (0.75, 0.97) | 0.56 (0.52, 0.64) | 0.61 (0.52, 0.67) | 0.59 (0.52, 0.84) | 0.7 (0.58, 0.95) | 0.57 (0.52, 0.68) | 0.58 (0.54, 0.71) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.1 (0.041, 0.141) | 0.033 (0.007, 0.059) | 0 (0, 0.149) | 0 (0, 0.044) | 0.102 (0.036, 0.196) | 0 (0, 0.056) | 0.062 (0, 0.131) | 0 (0, 0.081) | ||||||||||
| Carboplatin | count | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | |||||||||
| time | 10 (8, 14) | 10 (8, 14) | 10 (8, 14) | 10 (8, 14) | 10 (8, 14) | 10 (8, 14) | 10 (8, 14) | 10 (8, 14) | ||||||||||
| n | 10 (5, 14) | 4 (1, 9) | 3 (2, 4) | 2 (1, 3) | 2 (0, 3) | 3 (1, 5) | 5 (3, 6) | 2 (0, 5) | ||||||||||
| post_p | 0.77 (0.67, 0.87) | 0.61 (0.54, 0.79) | 0.63 (0.54, 0.77) | 0.56 (0.51, 0.68) | 0.64 (0.57, 0.72) | 0.55 (0.52, 0.66) | 0.77 (0.74, 0.88) | 0.71 (0.57, 0.88) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.1 (0.059, 0.142) | 0.044 (0, 0.09) | 0.042 (0, 0.091) | 0 (0, 0.084) | 0 (0, 0.046) | 0.074 (0, 0.103) | 0.024 (0, 0.054) | 0 (0, 0.04) | ||||||||||
| Niraparib | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |||||||||
| time | 15 (10, 17) | 15 (10, 17) | 15 (10, 17) | 15 (10, 17) | 15 (10, 17) | 15 (10, 17) | 15 (10, 17) | 15 (10, 17) | ||||||||||
| n | 9 (9, 20) | 4 (1, 8) | 6 (3, 7) | 2 (1, 6) | 3 (2, 5) | 3 (2, 4) | 3 (2, 4) | 2 (1, 4) | ||||||||||
| post_p | 0.74 (0.72, 0.84) | 0.62 (0.55, 0.7) | 0.78 (0.6, 1) | 0.6 (0.57, 0.69) | 0.6 (0.56, 0.8) | 0.62 (0.56, 0.83) | 0.7 (0.63, 0.79) | 0.7 (0.62, 0.81) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.094 (0.072, 0.1) | 0.076 (0.021, 0.086) | 0 (0, 0.01) | 0.038 (0, 0.082) | 0.043 (0, 0.221) | 0.027 (0, 0.094) | 0 (0, 0.065) | 0 (0, 0.02) | ||||||||||
| DRD+ | Carboplatin | count | 164 | 164 | 164 | 164 | 164 | 164 | 164 | 164 | ||||||||
| time | 18 (11, 34) | 18 (11, 34) | 18 (11, 34) | 18 (11, 34) | 18 (11, 34) | 18 (11, 34) | 18 (11, 34) | 18 (11, 34) | ||||||||||
| n | 8 (3, 19) | 8 (3, 18) | 5 (1, 11) | 5 (1, 11) | 5 (1, 12) | 4 (1, 11) | 4 (1, 12) | 4 (1, 11) | ||||||||||
| post_p | 0.8 (0.57, 0.96) | 0.73 (0.54, 0.86) | 0.76 (0.56, 0.94) | 0.74 (0.54, 0.91) | 0.82 (0.56, 0.97) | 0.7 (0.53, 0.9) | 0.78 (0.56, 0.96) | 0.72 (0.53, 0.91) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.028 (0, 0.056) | 0.023 (0, 0.043) | 0.026 (0, 0.074) | 0.023 (0, 0.062) | 0.031 (0, 0.072) | 0.025 (0, 0.066) | 0.031 (0, 0.076) | 0.025 (0, 0.059) | ||||||||||
| Niraparib | count | 172 | 172 | 172 | 172 | 172 | 172 | 172 | 172 | |||||||||
| time | 20 (11, 32) | 20 (11, 32) | 20 (11, 32) | 20 (11, 32) | 20 (11, 32) | 20 (11, 32) | 20 (11, 32) | 20 (11, 32) | ||||||||||
| n | 8 (3, 17) | 8 (3, 18) | 5 (1, 10) | 5 (1, 10) | 4 (1, 10) | 4 (2, 12) | 4 (2, 10) | 4 (1, 11) | ||||||||||
| post_p | 0.79 (0.62, 0.94) | 0.73 (0.55, 0.88) | 0.79 (0.55, 0.96) | 0.72 (0.53, 0.9) | 0.78 (0.53, 0.97) | 0.71 (0.53, 0.91) | 0.77 (0.55, 0.95) | 0.7 (0.55, 0.91) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.028 (0, 0.055) | 0.022 (0, 0.042) | 0.029 (0, 0.076) | 0.025 (0, 0.059) | 0.025 (0, 0.079) | 0.025 (0, 0.069) | 0.034 (0, 0.079) | 0.026 (0, 0.063) | ||||||||||
| TEfus+ | Hormone_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| time | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | 16 (16, 16) | ||||||||||
| n | 1 (1, 1) | 10 (10, 10) | 2 (2, 2) | 1 (1, 1) | 3 (3, 3) | 6 (6, 6) | 1 (1, 1) | 1 (1, 1) | ||||||||||
| post_p | 0.62 (0.62, 0.62) | 0.75 (0.75, 0.75) | 0.67 (0.67, 0.67) | 0.62 (0.62, 0.62) | 0.56 (0.56, 0.56) | 0.78 (0.78, 0.78) | NA (NA, NA) | 0.6 (0.6, 0.6) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0 (0, 0) | 0.058 (0.058, 0.058) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.113 (0.113, 0.113) | 0.298 (0.298, 0.298) | 0 (0, 0) | ||||||||||
| Taxel_therapies | count | 197 | 197 | 197 | 197 | 197 | 197 | 197 | 197 | |||||||||
| time | 14 (9, 30) | 14 (9, 30) | 14 (9, 30) | 14 (9, 30) | 14 (9, 30) | 14 (9, 30) | 14 (9, 30) | 14 (9, 30) | ||||||||||
| n | 6 (2, 17) | 17 (9, 39) | 3 (1, 10) | 2 (0, 6) | 6 (2, 15) | 5 (2, 14) | 2 (0, 6) | 2 (0, 6) | ||||||||||
| post_p | 0.73 (0.55, 0.9) | 0.93 (0.75, 1) | 0.57 (0.51, 0.79) | 0.63 (0.52, 0.87) | 0.84 (0.61, 0.98) | 0.79 (0.58, 0.98) | 0.6 (0.51, 0.79) | 0.6 (0.52, 0.82) | ||||||||||
| r_prob | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.025 (0, 0.049) | 0.035 (0.014, 0.065) | 0 (0, 0.041) | 0 (0, 0.051) | 0.029 (0, 0.058) | 0.028 (0, 0.074) | 0 (0, 0.06) | 0 (0, 0.053) | ||||||||||
| Carboplatin | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||||||
| time | 12 (11, 13) | 12 (11, 13) | 12 (11, 13) | 12 (11, 13) | 12 (11, 13) | 12 (11, 13) | 12 (11, 13) | 12 (11, 13) | ||||||||||
| n | 0 (0, 3) | 4 (2, 6) | 4 (3, 5) | 3 (1, 6) | 3 (2, 3) | 1 (0, 4) | 4 (2, 5) | 3 (2, 6) | ||||||||||
| post_p | 0.5 (0.5, 0.5) | 0.62 (0.56, 0.82) | 0.79 (0.64, 0.82) | 0.58 (0.55, 0.69) | 0.6 (0.52, 0.67) | 0.56 (0.52, 0.6) | 0.62 (0.58, 0.64) | 0.62 (0.59, 0.81) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0 (0, 0) | 0.032 (0.006, 0.056) | 0 (0, 0.067) | 0 (0, 0.076) | 0.087 (0.017, 0.119) | 0.03 (0.006, 0.055) | 0 (0, 0.022) | 0 (0, 0.012) | ||||||||||
| Niraparib | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |||||||||
| time | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | ||||||||||
| n | 0 (0, 1) | 6 (4, 8) | 6 (5, 6) | 6 (5, 8) | 0 (0, 1) | 2 (1, 2) | 4 (3, 5) | 3 (2, 4) | ||||||||||
| post_p | 0.59 (0.59, 0.59) | 0.79 (0.75, 0.83) | 0.73 (0.71, 0.76) | 0.72 (0.65, 0.79) | 0.55 (0.55, 0.55) | 0.55 (0.54, 0.56) | 0.64 (0.6, 0.67) | 0.6 (0.58, 0.63) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0 (0, 0) | 0.016 (0.003, 0.029) | 0 (0, 0) | 0.017 (0.003, 0.031) | 0 (0, 0) | 0.072 (0.014, 0.129) | 0.022 (0.004, 0.039) | 0 (0, 0) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| time | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | ||
| n | 10 (10, 10) | 2 (2, 2) | 7 (7, 7) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 2 (2, 2) | 2 (2, 2) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| post_p | 0.36 (0.36, 0.36) | 0.48 (0.48, 0.48) | 0.17 (0.17, 0.17) | 0.49 (0.49, 0.49) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.43 (0.43, 0.43) | 0.37 (0.37, 0.37) | NA (NA, NA) | 0.35 (0.35, 0.35) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.129 (0.129, 0.129) | 0 (0, 0) | 0.293 (0.293, 0.293) | 0.247 (0.247, 0.247) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.435 (0.435, 0.435) | 0.127 (0.127, 0.127) | NA (NA, NA) | 5.011 (5.011, 5.011) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||
| TP53- & AR- | count | 3 | 3 | 3 | 3 | |||||||||||||
| time | 9 (8, 9) | 9 (8, 9) | 9 (8, 9) | 9 (8, 9) | ||||||||||||||
| n | 24 (24, 26) | 5 (3, 7) | 0 (0, 0) | 0 (0, 3) | ||||||||||||||
| post_p | 0.4 (0.36, 0.47) | 0.46 (0.44, 0.48) | NA (NA, NA) | 0.35 (0.35, 0.35) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.099 (0.092, 0.101) | 0.063 (0.056, 0.073) | NA (NA, NA) | 0 (0, 0) | ||||||||||||||
| Taxel_therapies | count | 86 | 86 | 86 | 86 | |||||||||||||
| time | 21 (12, 32) | 21 (12, 32) | 21 (12, 32) | 21 (12, 32) | ||||||||||||||
| n | 15 (7, 36) | 7 (3, 15) | 4 (1, 7) | 4 (0, 8) | ||||||||||||||
| post_p | 0.13 (0.02, 0.38) | 0.44 (0.28, 0.49) | 0.29 (0.1, 0.4) | 0.42 (0.18, 0.49) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.153 (0.107, 0.25) | 0.069 (0.046, 0.132) | 0.198 (0.08, 1.121) | 0.066 (0.036, 0.209) | ||||||||||||||
| Carboplatin | count | 43 | 43 | 43 | 43 | |||||||||||||
| time | 17 (12, 30) | 17 (12, 30) | 17 (12, 30) | 17 (12, 30) | ||||||||||||||
| n | 18 (8, 40) | 4 (1, 7) | 5 (2, 10) | 6 (2, 8) | ||||||||||||||
| post_p | 0.18 (0.02, 0.39) | 0.26 (0.1, 0.39) | 0.42 (0.19, 0.49) | 0.38 (0.22, 0.46) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.156 (0.114, 0.204) | 0.198 (0.07, 0.82) | 0.087 (0.049, 0.345) | 0.057 (0.037, 0.122) | ||||||||||||||
| Niraparib | count | 51 | 51 | 51 | 51 | |||||||||||||
| time | 19 (13, 32) | 19 (13, 32) | 19 (13, 32) | 19 (13, 32) | ||||||||||||||
| n | 17 (5, 39) | 4 (1, 12) | 6 (2, 12) | 7 (3, 13) | ||||||||||||||
| post_p | 0.1 (0.01, 0.28) | 0.18 (0.06, 0.4) | 0.36 (0.19, 0.49) | 0.39 (0.22, 0.48) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.179 (0.129, 0.341) | 0.204 (0.093, 0.753) | 0.09 (0.051, 0.23) | 0.057 (0.037, 0.099) | ||||||||||||||
| TP53+ | Hormone_therapies | count | 275 | 275 | 275 | 275 | 275 | 275 | 275 | 275 | ||||||||
| time | 20 (12, 32) | 20 (12, 32) | 20 (12, 32) | 20 (12, 32) | 20 (12, 32) | 20 (12, 32) | 20 (12, 32) | 20 (12, 32) | ||||||||||
| n | 15 (7, 35) | 6 (3, 13) | 2 (0, 5) | 2 (0, 4) | 3 (1, 8) | 3 (1, 8) | 2 (0, 4) | 2 (0, 4) | ||||||||||
| post_p | 0.33 (0.1, 0.46) | 0.22 (0.07, 0.44) | 0.34 (0.21, 0.47) | 0.3 (0.16, 0.47) | 0.37 (0.19, 0.48) | 0.32 (0.16, 0.47) | 0.34 (0.2, 0.47) | 0.31 (0.15, 0.44) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.18 (0.14, 0.284) | 0.177 (0.107, 0.399) | 0.201 (0.1, 0.772) | 0.202 (0.07, 0.793) | 0.242 (0.143, 0.711) | 0.184 (0.107, 0.611) | 0.227 (0.104, 0.936) | 0.222 (0.088, 0.93) | ||||||||||
| DRD+ | count | 33 | 33 | 33 | 33 | 33 | 33 | 33 | 33 | |||||||||
| time | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | 28 (22, 35) | ||||||||||
| n | 4 (0, 8) | 4 (1, 9) | 2 (0, 8) | 3 (1, 5) | 3 (2, 6) | 4 (1, 6) | 3 (1, 4) | 3 (1, 5) | ||||||||||
| post_p | 0.36 (0.29, 0.5) | 0.41 (0.17, 0.48) | 0.32 (0.2, 0.44) | 0.29 (0.18, 0.4) | 0.28 (0.18, 0.46) | 0.25 (0.16, 0.39) | 0.36 (0.19, 0.46) | 0.24 (0.08, 0.38) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.094 (0.06, 0.158) | 0.076 (0.039, 0.122) | 0.181 (0.124, 0.626) | 0.189 (0.117, 0.59) | 0.237 (0.1, 0.514) | 0.181 (0.107, 0.643) | 0.209 (0.094, 0.445) | 0.205 (0.108, 0.722) | ||||||||||
| Taxel_therapies | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |||||||||
| time | 28 (22, 34) | 28 (22, 34) | 28 (22, 34) | 28 (22, 34) | 28 (22, 34) | 28 (22, 34) | 28 (22, 34) | 28 (22, 34) | ||||||||||
| n | 5 (3, 11) | 3 (1, 10) | 4 (1, 7) | 4 (1, 5) | 2 (1, 4) | 0 (0, 5) | 2 (1, 4) | 3 (2, 8) | ||||||||||
| post_p | 0.22 (0.08, 0.3) | 0.28 (0.18, 0.42) | 0.29 (0.16, 0.41) | 0.44 (0.36, 0.48) | 0.2 (0.18, 0.27) | 0.41 (0.35, 0.47) | 0.31 (0.27, 0.42) | 0.41 (0.29, 0.45) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.18 (0.114, 0.297) | 0.101 (0.063, 0.159) | 0.229 (0.099, 0.732) | 0.071 (0.055, 0.094) | 0.325 (0.18, 1.032) | 0.062 (0.042, 0.082) | 0.151 (0.127, 0.47) | 0.099 (0.05, 0.113) | ||||||||||
| TEfus+ | Hormone_therapies | count | 103 | 103 | 103 | 103 | 103 | 103 | 103 | 103 | ||||||||
| time | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | ||||||||||
| n | 5 (2, 15) | 7 (3, 14) | 3 (1, 10) | 2 (0, 5) | 4 (2, 8) | 4 (1, 8) | 2 (1, 5) | 2 (1, 4) | ||||||||||
| post_p | 0.41 (0.22, 0.49) | 0.21 (0.08, 0.41) | 0.39 (0.24, 0.48) | 0.3 (0.14, 0.44) | 0.29 (0.13, 0.46) | 0.31 (0.13, 0.45) | 0.28 (0.17, 0.42) | 0.31 (0.16, 0.43) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.082 (0.053, 0.162) | 0.173 (0.11, 0.407) | 0.069 (0.039, 0.19) | 0.193 (0.09, 0.622) | 0.213 (0.097, 0.561) | 0.187 (0.108, 0.545) | 0.192 (0.088, 0.809) | 0.199 (0.09, 0.79) | ||||||||||
| Carboplatin | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |||||||||
| time | 19 (15, 21) | 19 (15, 21) | 19 (15, 21) | 19 (15, 21) | 19 (15, 21) | 19 (15, 21) | 19 (15, 21) | 19 (15, 21) | ||||||||||
| n | 2 (2, 6) | 5 (3, 9) | 6 (5, 9) | 4 (0, 5) | 2 (0, 6) | 3 (3, 11) | 4 (2, 8) | 3 (2, 5) | ||||||||||
| post_p | 0.39 (0.18, 0.47) | 0.22 (0.09, 0.39) | 0.37 (0.32, 0.39) | 0.3 (0.18, 0.4) | 0.27 (0.2, 0.44) | 0.34 (0.23, 0.43) | 0.46 (0.3, 0.5) | 0.41 (0.23, 0.48) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.11 (0.064, 0.46) | 0.224 (0.153, 0.356) | 0.047 (0.03, 0.055) | 0.1 (0.073, 0.125) | 0.196 (0.091, 0.473) | 0.176 (0.152, 0.315) | 0.076 (0.032, 0.229) | 0.099 (0.068, 0.238) | ||||||||||
| Niraparib | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |||||||||
| time | 29 (14, 34) | 29 (14, 34) | 29 (14, 34) | 29 (14, 34) | 29 (14, 34) | 29 (14, 34) | 29 (14, 34) | 29 (14, 34) | ||||||||||
| n | 6 (5, 20) | 6 (3, 7) | 4 (3, 17) | 4 (3, 6) | 3 (1, 3) | 2 (1, 6) | 2 (1, 5) | 2 (1, 7) | ||||||||||
| post_p | 0.13 (0.02, 0.23) | 0.13 (0.07, 0.3) | 0.47 (0.37, 0.49) | 0.36 (0.29, 0.46) | 0.27 (0.18, 0.44) | 0.35 (0.25, 0.39) | 0.3 (0.22, 0.47) | 0.39 (0.29, 0.49) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.154 (0.135, 0.188) | 0.249 (0.155, 0.414) | 0.06 (0.041, 0.069) | 0.059 (0.048, 0.155) | 0.304 (0.108, 0.478) | 0.208 (0.147, 0.571) | 0.158 (0.103, 0.542) | 0.096 (0.078, 0.102) |